To use these NaturVet Calming Soft Chews, give them to your dog as directed on the package. Usually, it depends on your dog's weight. These chews are suitable for dogs over 12 weeks old. Make sure to keep the package in a cool, dry place. Don't leave it in direct sunlight or in a very hot area. If your dog has any special health conditions, it's a good idea to talk to your vet before starting to give these chews. Also, if you notice any strange reactions in your dog after giving the chews, stop using them and consult your vet right away.