To use these N - Bone Puppy Teething Rings, simply give one to your puppy when you notice them chewing on inappropriate things or showing signs of teething discomfort. It's a great way to redirect their chewing behavior. As for safety, always supervise your puppy while they're using the ring to prevent any choking hazards. If the ring gets dirty, you can wash it with mild soap and water. Keep the rings in a cool, dry place to maintain their quality. Replace the ring if it shows signs of excessive wear and tear to ensure your puppy's safety.